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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T21995 | XAP044 | GluR | |
XAP044 is a mGlu7-selective antagonist which inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice with a half-maximal blockade at 88 nm[1]. | |||
T61528 | FGFR-IN-7 | ||
FGFR-IN-7 (compound 17) is an orally active, potent FGFR modulator with the ability to penetrate the blood-brain barrier. It exhibits neuroprotective properties, enhancing brain exposure and decreasing the likelihood of ... | |||
T35873 | C19 Ceramide (d18:1/19:0) | C19 Ceramide (d18:1/19:0) | |
C19 Ceramide is a naturally occurring ceramide that has been found in J. juncea extracts as well as rat brain and mouse heart.[1],[2],[3] It is elevated in adult and decreased in juvenile whole rat brain extracts by 114 ... | |||
T79524 | JPC0323 | 5-HT Receptor | |
JPC0323 is a dual positive allosteric modulator of the 5-HT2C and 5-HT2A receptors, featuring on-target properties, acceptable plasma exposure, and adequate brain penetration. It is utilized in research pertaining to neu... | |||
T10443 | Aβ42-IN-1 free base | Others | |
Aβ42-IN-1 free base (compound 1v), an orally active γ-secretase modulator with high brain exposure, effectively lowers Aβ42 levels, exhibiting an IC 50 of 0.091 μM, and significantly diminishes brain Aβ42 levels in mice.... | |||
T63216 | γ-Secretase modulator 11 | ||
5-{8-[(3,4'-Difluoro[1,1'-biphenyl]-4-yl)methoxy]-2-methylimidazo[1,2-a]pyridin-3-yl}-N-methylpyridine-2-carboxamide (1o) exhibited high in vitro potency and brain exposure, was able to cause a significant reduction in b... | |||
T68356 | AM-3189 | ||
AM-3189 is a potent and selective GPR40 Agonist with minimal CNS penetration, superior pharmacokinetic properties and in vivo efficacy comparable to AMG 837. AM-3189 maintains the in vivo efficacy of AMG 837 while displa... | |||
T79666 | WLB-89462 | Sigma receptor | |
WLB-89462 (Compound 20c) is a selective σ2 receptor ligand with a K i of 13 nM, exhibiting neuroprotective properties and the ability to ameliorate Aβ peptide-induced short-term memory impairment in rats. It possesses a ... | |||
T36701 | Phosphoramide mustard (cyclohexanamine) | ||
Phosphoramide mustard cyclohexanamine is the major metabolite for Cyclophosphamide , with anticancer activitiy. Phosphoramide mustard cyclohexanamine induces DNA adduct formation in ovarian granulosa cells, induces DNA d... |